Sara Sampaio began her career after winning the contest Cabelos pantene 2007. She has appeared in numerous magazines such as Elle, Vogue, Glamour and many others. In 2012 she appears on the cover of Vogue Portugal, and was chosen to be the international image of the campaign Calzedonia for sea, where she is confirmed again in 2013, 2014 and 2015. She has also appeared in campaigns Replay and Blumarine along with Irina Shayk and Adriana Lima for seasons autumn / winter 2011/2012. In 2012, 2013 and 2014 is testimonial, along with Barbara Palvin, of the clothing line bridal Rosa Clara.
In 2013 she appears on the cover of GQ for the January issue, which is presented as “the eighth wonder of the world“, and parading at Calzedonia Summer Show. Also is chosen as the protagonist for the campaign 2013/2014 autumn / winter of Morellato.
In 2014 was chosen to be testimonial campaign of Agua Bendita spring / summer and confirmed for Morellato. Makes her debut in the magazine Sports Illustrated Swimsuit Issue, where Portuguese is the first model to appear on the magazine. Also is chosen as the face of Gas Jeans fall / winter 2014 next to motorcycling champion Marc Márquez.
In 2015 she starred in a sexy commercial for the fast food chain Carl Jr, to publicize the new cheesburgher El Diablo. In 2016 she is inserted, from models.com site, in the ranking of the sexiest models, and participate in the fashion week in Paris catwalks for Elie Saab, Jean Paul Gaultier, Balmain, and Miu Miu. In May gets her first cover in the United States, photographed by Gilles Bensimon for Maxim.