Leighton Meester began her acting career in 1999, at age 13, when she debuted on TV in an episode of Law & Order. At 14, he moved to Los Angeles, California, to work more steadily in the entertainment world. In a very short time, she appeared in a successful series such as 24, Crossing Jordan, Entourage, 7th Heaven and Veronica Mars, arriving later also to obtain major roles in the TV series Surface and Tarzan. In 2003, she made her film debut in the independent film Hangman’s Curse based on the homonymous book by Frank Peretti. Subsequently, in 2006, she played in Flourish alongside Jesse Spencer and Jennifer Morrison and appeared in the dramatic Inside. In the same year, she got her first film-driven part with the horror Drive Thru, for which she also recorded a piece of the soundtrack. Parallel to the film career also continues that on television: appears in other series as House, M.D., Shark, and CSI: Miami.
The breakthrough came in 2007 when Leighton Meester reached international fame thanks to the teen drama Gossip Girl, a series focused on the life of a group of rich youngsters from the Upper East Side of New York, where she played the role of Blair Waldorf, one of the protagonists. In the same year, she played in the television movie Mortal College. Despite the television success, the film career continues with The Beautiful Ordinary and Killer Movie (2008). In 2010 she played a small role in the film Date Night; in the same year, it released Country Strong, a musical film in which she stars alongside Gwyneth Paltrow and country singer Tim McGraw, in which she also sings the song Words I Could not Say. She also gets the starring role in three films: the thriller The Roommate, the independent film The Oranges with Hugh Laurie and the comedy Monte Carlo with Katie Cassidy and Selena Gomez, all coming out in 2011.
In 2012 she takes part in the comedy That’s My Boy, alongside Adam Sandler, Andy Samberg, and Milo Ventimiglia. In August, together with Wilmer Valderrama, she appeared in the video of the song Addicted to Love by Nomads and at the beginning of December, she began filming the movie By the Gun with Ben Barnes. She also enters the cast of Any Tom, Dick, or Harry.
In April 2013 her participation in the film The Judge is announced, with Robert Downey Jr., in May that in Life Partners, with Gillian Jacobs and Adam Brody, and in September that in Like Sunday, Like Rain by Frank Whaley, in which she plays Billie’s girlfriend Joe Armstrong