Riley Keough debuted as an actress in 2010 in the film The Runaways by Floria Sigismondi, biopic on the homonymous rock group of the seventies, where Keough plays Marie Currie, sister of Cherie Currie. In 2011 she starred opposite Orlando Bloom in the thriller The Good Doctor. In 2013 participated as a protagonist in the song video TKO of Justin Timberlake. In 2014 she starred in the advertising campaign Miu Miu Women’s Tales No.7. She was nominated for the award for the Best Performance by an Actress in a Mini-Series or a Motion Picture Made for Television for the Golden Globes 2016 thanks to the TV series The Girlfriend Experience.