Born in Rhode Island, the daughter of Ando Suvari (one psychoanalyst Estonia from Pärnu) and Candice Chambers (American nurse with Greek origins), Mena Suvari began modeling career in 1991, at the age of twelve. In 1995 she appears in the television series Boy Meets World and E.R., making her debut in 1997 in a film, Nowhere, directed by Gregg Araki.
The fame arrives in 1999, in the role of the young, disturbing and unbelievable hot Angela in American Beauty, starring Kevin Spacey. The interpretation makes getting a BAFTA nomination for Best Supporting Actress. In the same year plays the role of Heather in the adolescent comedy American Pie. Also in 1999, also she appears in the video for the Dirtbag by Wheatus.
Following the success achieved in this film, Mena Suvari appears in many Hollywood productions, such as co-star in movies like American Pie 2 and American School. In 2004 she plays the role of a lesbian poet in Six Feet Under and in 2006 plays one of the girls in the controversial Factory Factory Girl.
Mena Suvari was married on March 4, 2000 to April 24, 2005 with the director of photography Robert Brinkmann, 18 years older. In 2007, she knows the producer Simone Sestito, who married in Vatican City on 26 June 2010. The couple divorced in October 2012.