After studying at Pacific Academy in Surrey, Jessica Lowndes was spotted by the producer of the Masters of Horror series, who takes her in an episode of the series. Between 2005 and 2008 she participates in various television and film productions as Kyle XY and Greek, not as long as in 2008 she was awarded by the title role in the film Autopsy, an horror movie directed by Adam Gierasch.
Later the actress was chosen to play the character of Adrianna Tate-Duncan in the television series 90210. The character of Adrianna was originally conceived as a guest star in a few episodes, but their success has convinced the producers to make it a regular cast of the series.
Jessica Lowndes is also an aspiring singer and songwriter. A song written by her, Goodbye, was used in the soundtrack of an episode of the series Moonlight. She has a duet with Ironik and participated in the making of the video of their song Falling In Love. On September 11, 2014 Jessica Lowndes released her new single “Silicone In Stereo“. The official music video premiered on September 6, 2014—both on YouTube and Vevo. The song peaked at number 35 on Billboard Canada’s Top 50 and number 65 on the US Top 100.
Jessica Lowndes was also included on People magazine’s list of World’s Most Beautiful People of 2009, along with co-stars from the series 90210.